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Home - Products - MAPK/ERK Signaling - Ras - K-Ras G12C-IN-4

K-Ras G12C-IN-4

CAS No. 2376328-55-9

K-Ras G12C-IN-4( —— )

Catalog No. M26268 CAS No. 2376328-55-9

K-Ras G12C-IN-4 is a potent co-valent Inhibitor of KRAS G12C.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    K-Ras G12C-IN-4
  • Note
    Research use only, not for human use.
  • Brief Description
    K-Ras G12C-IN-4 is a potent co-valent Inhibitor of KRAS G12C.
  • Description
    K-Ras G12C-IN-4 is a potent co-valent Inhibitor of KRAS G12C.(In Vitro):Administration of K-Ras G12C-IN-4 for 4 hours inhibits MAPK signaling (p-ERK) in MIA PaCa-2 cells with IC50 of 0.219 μM. In the CellTiter-Glo assay of MIA PaCa-2 cells, the use of K-Ras G12C-IN-4 for 72 hours inhibited its cell viability with IC50 of 0.067 μM.
  • In Vitro
    K-Ras G12C-IN-4 (4 hours) exhibits IC50=0.219 μM for inhibition of MAPK signaling (p-ERK) in MIA PaCa-2 cells.K-Ras G12C-IN-4 (72 hours) translates to a 0.067 μM IC50 for inhibition of cellular viability in a CellTiter-Glo experiment in MIA PaCa-2 cells.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    MAPK/ERK Signaling
  • Target
    Ras
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2376328-55-9
  • Formula Weight
    561.08
  • Molecular Formula
    C31H33ClN4O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 62.5 mg/mL (111.39 mM)
  • SMILES
    COc1cccc2CN(CCc12)C(=O)c1c(C2CC2)n(CC(=O)NC2CN(C2)C(=O)C=C)c2c(C)cc(Cl)cc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Gu W, Silverman RB. Synthesis of (S)-2-Boc-Amino-8-(R)-(tert-butyldimethylsilanyloxy) decanoic acid, a Precursor to the Unusual Amino Acid Residue of the Anticancer Agent Microsporin B. Tetrahedron Lett. 2011 Oct 19;52(42):5438-5440.
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